Phis-peg
Webb1 mars 2014 · The dual thermo- and pH-responsive properties of the PHis-PLGA-PEG-PLGA-PHis copolymers as well as their potential for the delivery of anticancer drugs have not been investigated to date. In addition, the copolymer featured a large proportion of hydrophobic blocks (PLGA and PHis) in its molecular structure, which could enable good … Webb4 nov. 2015 · In order to overcome drug resistant and enhance antitumor activity of DOX, a new pH-sensitive micelle (DOX/DQA-DOX@DSPE-hyd-PEG-AA) was prepared to simultaneously deliver DOX to nucleus and ...
Phis-peg
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Webb24 okt. 2012 · Because further disruption of the micelle core forces ionized PHIS-PEG unimers to dissociate from the micelles, making micelles disintegrate and aggregate … WebbSynthesis of PHis-b-PEG-b-PHis triblock copolymer (PEG-PHis) The triblock copolymer was synthesized by polymerizing histidine monomer (PhO-His (Trt)-OH) using amino …
WebbThe pathways of LHRH-PEG-PHIS-Dox/Dox-TAT micelles entering into tumor cells. Materials and methods Materials Poly (L-histidine) (PHIS) with a number average molecular weight of 15,000 Da (as verified by gel-permeation chromatography) was purchased from Sigma Chemical Co. NHS-polyethylene glycol-COOH (NHS-PEG-COOH; … WebbSemantic Scholar profile for Wen-bing Liu, with 1 highly influential citations and 3 scientific research papers.
WebbMoreover, PHis-based nanocarriers achieved endo-somal escape in acidic subcellular compartments such as endosomes through proton sponge effect. PHis-based nanocarriers have thus great potential as an acid triggering tumor-killing platform [25–28]. For example, Bae et al. described that pH-sensitive PHis-PEG/PLLA-PEG mixed micelles were ... WebbThe synthesis scheme of PHIS-PEG 2000 and 7pep-DSPE-PEG 2000 is illustrated in Figure 1A. The PHIS-PEG 2000 was synthesized via a reaction between the amine group of the …
Webb15 apr. 2015 · A dual functional nano-scaled drug carrier, comprising of a targeting ligand and pH sensitivity, has been made in order to increase the specificity and efficacy of the …
Webb15 aug. 2012 · To overcome the limitations of monomeric pH probes for acidic tumor environments, this study designed a mixed micelle pH probe composed of polyethylene glycol (PEG)-b- poly(L-histidine) (PHis) and PEG-b-poly(L-lactic acid) (PLLA), which is well-known as an effective antitumor drug carrier.Unlike monomeric histidine and PHis … dwarf korean lilac bush careWebbFmoc-NH-(PEG)-COOH (9 atoms) Novabiochem®; CAS Number: 166108-71-0; Synonyms: Fmoc-NH-(PEG)-COOH (9 atoms),Fmoc-8-amino-3,6-dioxaoctanoic acid; find Sigma … crystal crawford pchWebbThe pH sensitivity was confirmed by changes in particle size, critical micelle concentration, and transmittance as a function of pH. MTT assay showed that PHIS/FA/PM had higher … dwarf knockout rose bushWebb27 apr. 2024 · In brief, mal-PEG-PLGA was dissolved in acetone, dried with nitrogen, and hydrated overnight in PBS (pH = 6.5). mal-PEG-PLGA was then mixed with SP94 peptide at a 1:1 molar ratio in PBS (pH = 6.5). The mixture … dwarf kowhai for saleWebb14 apr. 2015 · A dual functional nano-scaled drug carrier, comprising of a targeting ligand and pH sensitivity, has been made in order to increase the specificity and efficacy of the … dwarf korean lilac bushescrystal crawford pch winnerWebbThe AUC (0–∞), C max, and t 1/2 of the CUR-loaded micelles were increased by 2.07-fold, 3.14-fold, and 1.42-fold, respectively compared to CUR solution. 63 An endosomal micellar delivery system (F-pHSM-L61/CUR/Dox) consisting of a folate targeting ligand, poloxamer 407 (F127), and the pH-sensitive copolymer of PHis-PLA-PEG-PLA-Phis was used ... dwarf korean lilac shrub information