WebHepatotoxicity: TUKYSA can cause severe hepatotoxicity. In HER2CLIMB, 8% of patients who received TUKYSA had an ALT increase >5 × ULN, 6% had an AST increase >5 × ULN, and 1.5% had a bilirubin increase >3 × ULN (Grade ≥3). Hepatotoxicity led to TUKYSA dose reductions in 8% of patients and TUKYSA discontinuation in 1.5% of patients. Web21 sep. 2024 · The KEYNOTE-716 phase 3 trial showed that Keytruda (pembrolizumab), an anti-PD-1 therapy, showed clinically meaningful and statistically significant improvement in recurrence-free survival (RFS) compared with the placebo for individuals with resected high-risk stage 2 melanoma, Merck said in a statement.

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