Hif1a breast cancer
WebNational Center for Biotechnology Information WebHIF1A. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC.
Hif1a breast cancer
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Web30 de jun. de 2016 · HIF1α accumulation in TNBC lines is posttranscriptional because HIF1A mRNA levels are not increased in TNBC cell lines compared to other breast cancer subtypes (Figure 1E). Of note, the protein levels of the EglNs that mark HIFα for destruction are not decreased in TNBC lines compared to hormone-responsive and HER2-positive … Web1 de jul. de 2010 · Cell cultures and reagents. Human breast cancer cell lines MDA-MB-231, MCF-7, MDA-MB-468, SK-BR-3 and MDA-MB-453 were obtained from the Department of Pathology, Peking University Medical Science Center, and were cultured in DMED medium or RPMI-1640 with 10% fetal bovine serum at 37°C in a humidified environment …
Web2 de mar. de 2024 · Evidence suggests that ATP [ 14] and HIF-1α are closely associated with breast cancer chemoresistance [ 23] as well as drug resistance in multiple other … Web3 de abr. de 2014 · In breast cancer cell line models, depletion of XBP1 inhibited tumour growth and tumour relapse and reduced the CD44(high)CD24(low) population. Hypoxia …
Web25 de jan. de 2024 · miR-153 inhibits hypoxia-induced HIF1α expression in breast cancer cells. There is a consensus miR-153-binding site at the HIF1A-3′-UTR (Fig. 1a).To test whether miR-153 directly targets HIF1α ... Web28 de jul. de 2014 · In this study, we investigated the function of miR-18a in regulating breast cancer metastasis through the hypoxia-inducible factor 1α (HIF1A)–dependent hypoxic response. An orthotopic metastatic breast cancer xenograft model (MDA-MB-231 cells) was used to identify miRNAs associated with spontaneous lung metastasis.
Web8 de abr. de 2024 · Studies on Notch-mediated hypoxia-induced EMT mainly concentrated on breast cancer cells, ... Guo Y, Zhang Y, Duo A, Jia Y, Liu C, et al. PAFAH1B2 is a HIF1a target gene and promotes metastasis in pancreatic cancer. Biochem Biophys Res Commun. (2024) 501:654–60. doi: 10.1016/j.bbrc.2024.05.039. PubMed Abstract CrossRef Full …
Web17 de ago. de 2011 · Primary tumors facilitate metastasis by directing bone marrow-derived cells (BMDCs) to colonize the lungs before the arrival of cancer cells. Here, we demonstrate that hypoxia-inducible factor 1 (HIF-1) is a critical regulator of breast cancer metastatic niche formation through induction of multiple members of the lysyl oxidase (LOX) family, … razor icon foldable scooterWeb3 de ago. de 2024 · HIF1A can act a tumor suppressor by preventing expression of PPP1R1B and subsequent degradation of the p53 protein in pancreatic cancer cells, which reduces their invasive and metastatic activity. BACKGROUND & AIMS Pancreatic ductal adenocarcinomas (PDACs) are hypovascular, resulting in the upregulation of hypoxia … razor images from .netWeb5 de ago. de 2016 · Breast cancer is the most frequently diagnosed form of cancer in American women and is the second leading cause of cancer-related deaths, primarily due to the incurable nature of metastatic breast cancer [].Metastasis is the process whereby cancer cells spread from the site of the original tumor to distant organs [].A stepwise … razor image syntaxWebSignificant associations between HIF-1α overexpression and patient mortality have been shown in cancers of the brain (oligodendroglioma), breast, cervix, oropharynx, ovary … razor if check text like thenWeb8 de jul. de 2024 · Significance. We demonstrated that early B cell factor 1 (EBF1) is highly expressed in triple-negative breast cancer (TNBC) cells, and knockdown of EBF1 … simpson street church of christ atlanta gaWeb14 de abr. de 2024 · Abstract. Hypoxia-inducible factor 1 alpha (HIF1A) activation drives cellular adaption to low oxygen stress in malignant and non-malignant cells. HIF1A transcriptionally regulates many genes in key processes like angiogenesis and metastasis, facilitating the cell’s survival. Interestingly, HIF1A is able to carry out its regulatory … simpson stringer connectorWeb5 de ago. de 2024 · This study also identified PPP1R1B, a gene negatively regulated by HIF1A, as a key promoter of metastasis in pancreatic cancer. Elevated expression of PPP1R1B has been associated with advanced disease and poor prognosis in several cancers, including breast and lung cancer. razor if user is authenticated