WebResults: We identified seven clusters in healthy human meniscus, including five empirically defined populations and two novel populations. Pseudotime analysis showed … WebJun 14, 2016 · Fibrochondrocytes and fibroblasts are the two cell types found within the disc [ 2, 4, 6, 7 ]. Fibrochondrocytes predominate within the disc itself, and fibroblasts …
IJMS Free Full-Text Distal-Less Homeobox 5 Is a Therapeutic …
WebJan 18, 2024 · Abstract. Unexpectedly, we found that c-Myc-expressing porcine embryonic fibroblasts (PEFs) subcutaneously implanted into nude mice formed cartilage-like tissues … WebApr 7, 2024 · We delineated an atlas of human meniscus cells at fibrosis initiation using single-cell sequencing and found that smooth muscle cells in embryonic meniscus are the precursor cells of fibrochondrocyte progenitors in the mature meniscus, determinant for fibrosis. In vivo NOTCH3 inhibition impaired meniscus fibrosis by smooth muscle cells … galltec+mela krc3/5
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WebProteolytic fragments of fibronectin can have catabolic effects on cartilage, menisci, and synovium. Previous studies have reported that Toll-like receptor (TLR) signaling pathways might be associated with joint inflammation and joint destruction. Platelet-rich plasma (PRP) is increasingly being used to treat a range of joint conditions; however, it has yet to be … WebChondrocyte hypertrophy is a hallmark of osteoarthritis (OA) pathology. In the present study, we elucidated the mechanism underlying the relationship between the hypertrophy/apoptotic phenotype and OA pathogenesis in bone marrow-derived mesenchymal stem cells (BM-MSCs) via gene targeting of distal-less homeobox 5 (DLX5). Our primary objectives were … WebFibrochondrogenesis is a congenital disorder presenting several features and radiological findings, some which distinguish it from other osteochondrodysplasias. [7] These include: … galltec edj2/2