WebCTCF. Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [5] [6] CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V (D)J recombination [7] and regulation of chromatin architecture. [8] WebCTCF’s role in tumor suppression is further demonstrated in vivo using CTCF hemizygous knockout mice, which have a significantly higher chance to succumb to different types of cancer including uterine tumors, T cell lymphoma, and B cell lymphoma by 100 weeks of age in comparison to their WT counterparts. Furthermore, CTCF hemizygous knockout ...
CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 ... - Nature
WebApr 1, 2024 · CTCF and CTCFL in cancer. CTCF plays a key role in organizing chromatin into TAD structures but it can also function as a transcription factor. CTCFL (CTCF-like), the paralog of CTCF, is normally transiently expressed in pre-meiotic male germ cells together with ubiquitously expressed CTCF. It plays a unique role in spermatogenesis by ... WebApr 14, 2024 · Due to their critical role, eRNAs are often dysregulated in cancer and growing number of interactions with chromatin modifiers, transcription factors, and splicing machinery have been described. ... Numerous studies have shown that CTCF regulates enhancer–promoter interactions and the human genome contains thousands of CTCF … songs that make girls twerk
Cancer-specific CTCF binding facilitates oncogenic
WebJan 21, 2024 · BackgroundGenes spanning long chromosomal domains are coordinately regulated in human genome, which contribute to global gene dysregulation and carcinogenesis in cancer. It has been noticed that epigenetic modification and chromatin architecture may participate in the regulation process. However, the regulation patterns … WebCTCF’s role in tumor suppression is further demonstrated in vivo using CTCF hemizygous knockout mice, which have a significantly higher chance to succumb to different types of … WebCTCF is thought to be a primary part of the activity of insulators, sequences that block the interaction between enhancers and promoters. CTCF binding has also been both shown to promote and … songs that make you cry 2020